1. 基本信息
段东柱,甘肃通渭县人,博士、副教授,硕士研究生导师,陕西省中医药科研创新人才。2008年毕业于陇东学院生物科学专业,获理学学士学位,2011年毕业于兰州理工大学微生物与生化药学专业,获理学硕士学位,2014年毕业于兰州大学有机化学专业,获理学博士学位。2014年8月至2015年7月,任职于贵州医科大学基础医学院,2018年至2019年,作为访问学者在中国科学院昆明动物所进行肿瘤生物学研究,2015年7月进入宝鸡文理学院化学化工学院工作至今。已在包括J. Biol. Chem., Mol. Cancer, Free Radic. Biol. Med. (4), Bioorg. Chem., J. Am. Chem. Soc.等化学与生物医学国际主流SCI期刊发表学术论文近50篇,文章已被引用近3000次,H指数为28。担任Redox Biology, Free Radical Biology and Medicine, Phytomedicine等国际期刊审稿人。
2. 研究方向
(1)药物化学生物学。
(2)生化药理学。
3. 开设课程
承担了《天然药物化学》、《有机化学实验》、《物理化学实验》、《化学教育文献选读》等本科生和研究生的课程。
4. 主持科研项目
(1)国家自然科学基金面上项目(82073316):五味子三萜逆转HECTD3泛素化修饰p62诱导自噬促进三阴性乳腺癌细胞耐药的研究,项目负责人。
(2)陕西省中医药科研创新人才项目:(2025-CXRC-11),陕西道地药材中以硫氧还蛋白还原酶为靶点抗癌药效物质基础及作用机制研究,项目负责人。
(3)陕西省科技厅项目(2018JQ2051):以TrxR和Hsp90为双靶点的抗肿瘤成分发现及作用机理,项目负责人。
(4)陕西省教育厅重点项目:(16JS009),基于两种秦岭特色药用植物的硫氧还蛋白还原酶抑制剂的发现及抗肿瘤机制研究,项目负责人。
5. 发表论文
(1)Peng Song#,Tongtong#, Yinfang Zhang#, Tingting Shao#, Rongkun Li, Chaoxia An, Lu-Qi Cao, Zhe-Sheng Chen*, Wenjing Guo*,Dongzhu Duan*. Traditional Chinese Medicine in the Treatment of Breast Cancer. Molecular Cancer, 2025, 24:209.
(2)Dongzhu Duan*, Xing Yang, Xiangyu Guo, Mi Li, Xiaojie Jin, Le Wang, Jian Xiao, Xiaoling Wang*, Peng Song*. Interaction of glaucocalyxin a with glutathione and thioredoxin reductase for triple-negative breast cancer treatment. Bioorganic Chemistry, 2025, 161:108572.
(3)Qiyu Chen, Ruipeng Shen, Liangying Mi, Zhengyu Ma, Songhe Ni, Chunlin Sun, Haijuan Zhang, Jiang Wu, Dongzhu Duan*, Baoxin Zhang*. Imaging of sulfhydryl fluctuations in mouse models of drug-induced liver injury via a novel near-infrared fluorescence probe. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2025, 339:126289.
(4)Dongzhu Duan, Xiangyu Guo, Jingjing Tian, Mi Li, Xiaojie Jin, Zihua Wang*, Le Wang, Yunyun Yan, Jian Xiao*, Peng Song*, Xiaoling Wang*. Targeting thioredoxin reductase by eupalinilide B promotes apoptosis of colorectal cancer cells in vitro and in vivo. Chemico-Biological Interactions, 2024, 398:111137.
(5)Dongzhu Duan*, Yanru Wang, Dabo Pan, Xiaojie Jin, Yunyun Yan, Peng Song, Le Wang, Jian Xiao, Zihua Wang*, Xiaoling Wang*. Rheumatoid arthritis drug sinomenine induces apoptosis of cervical tumor cells by targeting thioredoxin reductase in vitro and in vivo. Bioorganic Chemistry, 2022, 122:105711.
(6)Dongzhu Duan*, Yanru Wang, Xiaojie Jin, Mi Li, Le Wang, Yunyun Yan, Jian Xiao, Peng Song*, Xiaoling Wang*. Natural diterpenoid eriocalyxin B covalently modifies glutathione and selectively inhibits thioredoxin reductase inducing potent oxidative stress-mediated apoptosis in colorectal carcinoma RKO cells. Free Radical Biology and Medicine, 2021, 177:15-23.
(7)Dongzhu Duan*, Yanru Wang, Dabo Pan, Le Wang, Jian Xiao, Peng Song*, Xiaojie Jin, Xiaoling Wang*. Targeting thioredoxin reductase by deoxyelephantopin from Elephantopus scaber triggers cancer cell apoptosis. Archives of Biochemistry and Biophysics, 2021, 711:109028.
(8)Junmin Zhang1, Dongzhu Duan1, Alsiddig Osama, Jianguo Fang*. Natural molecules targeting thioredoxin system and their therapeutic potentials. Antioxidants & Redox Signaling, 2021, 34:1083-1107. (1Co-first author)
(9)Dongzhu Duan, Junmin Zhang, Juan Yao, Yaping Liu, Jianguo Fang*. Targeting thioredoxin reductase by parthenolide Contributes to inducing apoptosis of HeLa cells. Journal of Biological Chemistry, 2016, 291:10021-10031.
(10)Liangwei Zhang, Dongzhu duan, Yaping Liu, Chunpo Ge, Jinyu Sun, Xuemei Cui, Jianguo Fang*. Highly selective off-on fluorescent probe for imaging thioredoxin reductase in Living Cells. Journal of the American Chemical Society, 2014, 136: 226-233.
6. 联系方式
通讯地址:陕西省宝鸡市渭滨区高新大道1号宝鸡文理学院明理楼
邮编:721013
邮箱: duandongzhu@126.com